Today's Edition
ABU DHABI (ALETIHAD)
In a groundbreaking advancement toward cell therapy and regenerative medicine, the Abu Dhabi Stem Cells Center (ADSCC) has successfully developed clinical-grade induced pluripotent stem cells (iPSCs) that comply with the Good Manufacturing Practice protocols and are, as such, compliant with the strictest international standards for clinical applications.
This has been accomplished by the scientists at ADSCC’s research laboratories in Abu Dhabi using their virus-free in-house, exclusive techniques, know-how and protocols.
This achievement, the first of its kind in the Middle East, positions ADSCC as a pioneer in stem cell research and sets a global benchmark for innovation and safety in precision medicine.
iPSCs are a cutting-edge innovation in biomedical science, to be used for a wide range of therapeutic applications, including the treatment of neurodegenerative diseases such as Parkinson’s, Alzheimer’s, and multiple sclerosis, as well as other conditions such as diabetes. ADSCC is currently running multiple research projects for the use of iPSCs in treating these diseases.
Derived by reprogramming adult cells, such as skin and blood cells, back to an embryonic-like state, iPSCs can differentiate into many types of cells in the human body. Moreover, iPSCs can be created from a patient’s cells, allowing for autologous, personalised therapies that minimise or even eliminate the risk of immune rejection and the need for immunosuppressive drugs.
Professor Yendry Ventura, CEO of ADSCC, and the Principal Investigator in ADSCC’s Capital Organ Regeneration (CORi) research project, said, “Developing our clinical-grade iPSCs using a proprietary, virus-free protocol is a monumental step forward for the UAE and the global medical community. This accomplishment reinforces Abu Dhabi's position as a hub for cutting-edge medical research and opens the door to transformative therapies that can address some of the most complex diseases. The success of this project reflects our commitment to delivering safe, innovative, and personalised solutions to patients worldwide. Our team of scientists will be publishing our scientific findings in leading medical journals.”
Unlike standard methods that rely on the use of viruses to reprogram cells, ADSCC’s protocol avoids genetic modification, significantly reducing the risk of cell transformation, tumour formation or other complications. The process adheres to the strictest clinical standards, making the iPSCs suitable for therapeutic use. This innovation underscores ADSCC’s commitment to developing regenerative therapies that are both safe and effective.
Professor Angelo Vescovi of the Link Campus University of Rome and Advisor at ADSCC, said, “Induced pluripotent stem cells are a cornerstone of personalised medicine. By creating iPSCs from a patient’s cells, we can generate therapeutic cells tailored to their needs. For example, iPSCs can be differentiated into neural (brain) stem cells for patients with neurodegenerative conditions that could be injected back through intracerebral transplantation in the brain and spinal cord or into pancreatic cells for diabetes. This protocol achieves these outcomes and does with improved safety and reliability, making it a significant advancement toward clinical applications.”
This development also marks a significant leap in ADSCC’s capacity to advance regenerative medicine locally. By establishing an exclusive, in-house protocol for iPSC development, the centre has built a robust foundation for future therapeutic applications and biomanufacturing. The ability to produce clinical-grade iPSCs within Abu Dhabi ensures greater control over the quality and availability of these groundbreaking therapies, reducing dependency on external sources.
Furthermore, ADSCC’s achievement aligns with the UAE’s vision as a global leader in healthcare innovation. With its state-of-the-art Good Manufacturing Practice (GMP) facilities and highly skilled research team, the centre is well positioned to translate the breakthrough into life-changing treatments.
Professor Yendry Ventura said, “This accomplishment is not just about scientific excellence; it’s about making a difference for patients. The capacity to produce iPSCs locally means we can offer hope to individuals suffering from debilitating diseases. The potential applications are vast, from treating neurological conditions to developing new therapies for chronic illnesses, which will be offered at our hospital in Abu Dhabi.”
ADSCC’s pioneering work with iPSCs demonstrates the centre's focus on advancing stem cell research and personalised medicine. By establishing a routine, clinical-grade process for iPSC development, ADSCC has laid the groundwork for future breakthroughs that could revolutionise healthcare globally and bring hope to countless patients.
